Which cells in the skin assist in immune responses?

Langerhans cells are a specialized type of dendritic cell found within the epidermis of the skin, and they play a crucial role in the immune response. These cells are part of the body's first line of defense and function primarily to capture and present antigens (foreign substances that induce an immune response) to T cells, which are essential components of the adaptive immune system.

When Langerhans cells encounter pathogens or foreign antigens, they ingest and process these particles before migrating to the lymph nodes. Here, they interact with T cells, helping to activate the immune response and initiate a reaction to eliminate the invading pathogens. This important function of Langerhans cells highlights their role in the skin as a critical component of the immune system, helping to maintain the body’s defenses against infections.

In contrast, fibroblasts are primarily involved in producing and maintaining the extracellular matrix of connective tissue; keratinocytes are the predominant cells in the epidermis responsible for forming the protective outer barrier of the skin; and melanocytes are responsible for the production of melanin, which gives skin its color and protects against UV radiation. While all these cells contribute to skin health and function, Langerhans cells specifically engage in immune processes, making them